Human–mouse immune atlas
Find genes, explore their immune functions, and compare reported human disease and mouse phenotypes.
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Find a gene
Search human or mouse genes. Choose a result to see its functions, phenotypes, expression and counterparts.
Genes in this atlas
Click a number to jump to its gene list. These totals are the Quest for Orthologs 2025_04 reference-proteome genes used by the Alliance/DIOPT algorithms, plus genes that already have an edge in the frozen Alliance 9.0.0 table. A proteome gene with no cross-species edge is unmatched.
“Human-only”, “mouse-only”, “both” and “neither” describe recorded immune phenotypes for the 17,720 selected pairs. They do not establish whether a gene has an immune function.
Genes
| Gene | Species | Mouse / human matches | What is known about immunity |
|---|
Gene map
Explore how much immune phenotype information is recorded for each selected human–mouse pair.
Larger points contain more genes with the same counts. Click a point to see them. The separate “IUIS only” lane contains genes with human immune disease evidence in IUIS but no immune HPO terms. It is not a negative HPO count. Logarithmic spacing makes small and large counts visible; more annotations do not mean stronger immune function.
Pathways and gene sets
Explore biological processes enriched among genes with human-only, mouse-only or shared immune phenotype evidence.
All five collections are recalculated using the same 17,720 selected pairs and current phenotype groups. Each panel has its own collection selector. For Reactome, the TAS-only option excludes mappings supported only by electronic annotation and recalculates the background and enrichment. TAS is not synonymous with direct human experimental evidence. The statistical background includes selected pairs annotated in that collection.
How to read a gene record
Human–mouse matches
Some genes have several possible counterparts. Phenotype comparisons use one selected pair; other matches remain available on the gene page.
Immune functions
Reactome describes biological pathways. A gene can participate in immunity even if no immune disease or knockout phenotype is recorded.
Reported phenotypes
HPO and IUIS provide human disease evidence. MGI and IMPC provide mouse phenotype records. A missing record does not prove that a gene has no immune role.